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PHARMAC Information sheet
Record the duration of increased temperature exposure. For example, the temperature of the freezer was 0 degrees Fahrenheit at noon on day 1 when the power failed; 15 degrees Fahrenheit at 6 PM on day 2 when the power was restored; 10 degrees Fahrenheit at 10 PM on day 2; and 0 degrees Fahrenheit at 7 AM on day 3. This information about time/temperature duration can enable calculations to be made by the product manufacturer, in consultation with FDA as necessary, about the continued potency of the involved products.
Pharmacology as a scientific discipline did not further advance until the mid-19th century amid the great biomedical resurgence of that period.[5] Before the second half of the nineteenth century, the remarkable potency and specificity of the actions of drugs such as morphine, quinine and digitalis were explained vaguely and with reference to extraordinary chemical powers and affinities to certain organs or tissues.[6]
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