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Most refrigerated vaccines are relatively stable at room temperature for limited periods of time, although certain vaccines are temperature-sensitive. Products stored in a closed refrigerator (or freezer, if appropriate) during a power outage may maintain their potency unless the power outage is of such duration that the refrigerator’s (or freezer’s) internal temperature rises significantly. It is recommended that thermometers be located in the refrigerator and freezer section so that temperatures can be read when power resumes to see if excursions outside of recommended temperatures have occurred. The „How Supplied/Storage and Handling“ section of the product label may also be consulted for information. Most vaccine manufacturers have filed data with CBER to support the stability of their products at somewhat elevated temperatures and related duration of storage; they may consult with CBER concerning the impact of temperature/time duration on product stability.
In broad terms, pharmacodynamics discusses the interactions of chemicals with biological receptors, and pharmacokinetics discusses the absorption, distribution, metabolism, and excretion of chemicals from the biological systems. Pharmacology is not synonymous with pharmacy and the two terms are frequently confused. Pharmacology deals with how drugs interact within biological systems to affect function.
well as a peculiar acid � meconic acid. The alkaloids are chiefly combined with meconic acid or sulphuric acid, but may be partly free. The three most important alkaloids are morphine, codeine, and thebaine. The others are papaverine, pseudomorphine or oxymorphine, gnoscopine, codamine, laudanine, laudanosine, meconidine, lanthopine, protopine, cryptopine, narcotine, oxy-
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